Mark Romanek was going to direct but left the project over budget disagreements.
'Benicio del Toro''s Wolfman make-up took approximately 3 hours to apply and 1 hour to remove.
When Rick Baker, who became a makeup artist because of The Wolf Man (1941), heard that this film was being made he called Universal to tell them he had to do the makeup. Universal told him that he was their one and only choice but that they didn't have anyway of making contact with him.